Research projects and contracts

Active projects

EuroNanoMed II project „PhOtocrosslinked hydrogels for guided periodontal TissUe Regeneration” (POsTURE)

Project leader: Assoc. Prof., Dr.sc.ing. Dagnija Loca - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Periodontitis, a recognized disease worldwide, is a serious gum infection that damages soft tissue and results in loss of tooth-supporting alveolar bone. Regenerative periodontal procedures aim to reverse this damage by using both a bone graft and a membrane to obtain complete tissue reconstruction. The multidisciplinary POsTURE project aims to develop an innovative periodontal regeneration device based on: (i) a self-setting injectable bone grafting material containing Sr, Mg or Si substituted CaP nanoparticles with enhanced bioactivity and (ii) a photo-cross-linked interpenetrating polymer network based on UV photosensitive methacrylated dextran that will be applied as a viscous solution and cured in situ with UV light, as a membrane to prevent excessive proliferation of gingival tissue.

National Research Programme No. 2014.10-4/VPP-3/21 “MultIfunctional Materials and composItes, photonicS and nanotechnology (IMIS2)” Project No. 4 “Nanomaterials and nanotechnologies for medical applications”

Project leader: Prof. Liga Berzina-Cimdina - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Develop new and improved innovative materials for medical applications, including implants for tissue replacement and regeneration, considering the fundamental and applied research results in the field and the latest advances in nanotechnology industry, as well as involving internationally recognized experts of various scopes with a motivated team of talented young scientists and specialists in coordinated research, while developing production and application technologies of new products through the capacity of newly established National Research Centers. Main project tasks:

  1. Creating and exploring new, exploitable and competitive biomaterials – nanostructured composite materials for bone and tissue implants.
  2. Develop and experimentally approbate new systems of optical biosensors for rapid microbiological quality control of food and environmental samples.
  3. Creating and exploring new, exploitable and competitive nano- and micro- carriers for targeted drug transport.

4.1. Subproject

Subproject leader: Assoc. Prof., Dr.sc.ing. Dagnija Loca - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Project aims to create and comprehensively characterize, including the in vitro and in vivo studies, new anti-bacterial and anti-osteoporotic biomaterials for regeneration of bones. Direction of the research aimed to solving the problem of an aging population, affecting people whose quality of life and mobility is dependent on musculoskeletal system diseases caused by bone dysfunction, which is the second most common cause of disability globally. In vivo and clinic studies of biphasic CaP bioceramic realized within the previous NRP have demonstrated a fundamental dependence of materials properties on the structural condition of patient's hard tissues as well as the dual effect of materials (increasing the reduced volume of atrophic bone through osteointegration, and the possibility of an osteoporotic bone remineralisation/reossification) into the bone tissues environment through long-term (more than five years) observations, paving the way to a novel treatment of osteoporosis locally. Modification of the CaP designed structurally by changing structural elements of the implant material from macro- to nano- levels or chemically by incorporating various substitutes and chemical elements that would provide specific desirable properties of the material allows developing alternative multifunctional biomaterials for the replacement or the reconstruction of functionality of various tissues.

RTU Scientific Research Project "Development of Production Method for High-Performance Nano-concrete with Low Water/Cement Ratio"

Project Leader. Project leader: Prof. Dr.sc.ing. Diana Bajare, Department of Building Materials and Products, Institute of Materials and Structures

Project Partner. Leader: Dr.sc.ing. Liga Stipniece, Institute of General Chemical Engineering

The project is planned to be implemented in cooperation between two RTU structural units - Department of Building Materials and Building Products, Institute of Materials and Structures and Institute of General Chemical Engineering (IGCE). The aim of the project is to develop a method for the production of high-performance nano-concrete by partly replacing with mineral, industrial by-products and production residues and thus reducing the amount of cement used, thereby promoting resource efficiency and increasing the environmental sustainability of products. Considering that the costs of production of cement are continuously increasing with the increase in the costs of electricity, it is expected that the introduction of high-performance nano-concrete production technology will significantly improve the economic performance of the merchant's business and increase competitiveness in the construction sector. The role of the IGCE is to determine the chemical and mineralogical composition of the raw materials used, as well as to study the binder and nano- or microfillers systems in order to create optimal compositions and to provide efficient cement hydration processes.

EuroNanoMed III project “NANOstructured oSteoChOndral scaffold: novel biomimetic tRiggErS for enhanced bone regeneration" (NANO-SCORES)

Project leader: Assoc. Prof., Dr.sc.ing. Janis Locs - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Degeneration of the articular osteochondral tissues causes pain and decreased function leading to osteoarthritis. Till now, only one osteochondral scaffold (developed by two partners of the project consortium) has been translated in the clinical practice to restore the damaged joint surface. Results have been satisfactory for the cartilage layer, but regeneration of the subchondral bone by the scaffold has to be improved. The NANO-SCORES project aims to improve this clinically tested osteochondral scaffold by introducing two new nano-strategies: (i) nanostructured “ion banks” in the form of amorphous calcium phosphate granules with Sr and (ii) bioactive peptides, such as SDF1, PDGFBB, BMP2 and GDF5 bioconjugated to the scaffold.

Cooperation project between RTU and RSU “Development of nanostructured bone replacement materials and study of immunological aspects in bone tissue regeneration"

Project leader: Assoc. Prof., Dr.sc.ing. Janis Locs - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Aim of the project is to develop several innovative technologies for bone regeneration. At first technology for obtaining of amorphous calcium phosphate and nanostructured calcium phosphate granules with high specific surface area (> 50 m2/g) will be developed. The obtained materials will go through in vitro and in vivo tests. Practical use of the nanostructured granules is foreseen in stomatology and plastic surgery. Secondly, new diagnostic methods for characterization of bone regeneration rate using biological material (e.g. blood, serum, biopsy) will be developed.

National Research Program of Latvia 2014-2017 within program No.6 project No.4 “Investigation of geological resources – new products and technologies (Earth)” subproject No.4

Subproject leader: Dr.sc.ing. Līga Bērziņa-Cimdiņa, RTU Institute of General Chemical Engineering

The aim of this project is to investigate and evaluate the application of Latvian clays in development of new products. Porous granular sorbent for water purification technology and sprayable biodegradable composite material for daily waste cover in landfills will be developed, as well as the ability of Latvian clays to stabilize emulsions and protect skin against UV radiation will be investigated.

Post-doctoral research project “Investigation of carbon containing materials and method development for heavy metal removal from water” 2018-2021

European Regional Development Fund within the Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”.
Project leader: Dr.sc.ing. Inga Jurgelāne, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The scientific aim of this project is to develop effective and environmental friendly adsorption materials with relatively low costs and laboratory size prototype for water purification from heavy metals. Shungite, hydroxyapatite and clays will be used as raw materials. The main tasks contain material preparation and characterization, adsorption of  Cu2+, Zn2+, Pb2+, Cd2+, Ni2+, Cr6+ and As5+  ions, regeneration of the used materials and development of laboratory size prototype.

Post-doctoral research project “Multifunctional calcium phosphate and biodegradable polymer composites for therapeutic bone tissue engineering” 2017-2020

European Regional Development Fund within the Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”. No. 1.1.1.2/VIAA/1/16/045
Project leader: Dr.sc.ing. Kristine Salma-Ancane - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Repair and healing fractures caused by osteoporosis or cancer still remains a major clinical challenge in orthopaedic surgery. The scientific objective of proposed project is to develop novel multifunctional composites and composite hydrogels based on nanosized hydroxyapatite and biodegradable polymers such as ɛ- poly(L-lysine) or poly(vinyl alcohol) loaded with the antiosteoporotic agent strontium ranelate or the anti-cancer drug doxorubicin for bone fracture healing and effective local therapeutic treatment of osteoporosis or bone cancer. The composites and composite hydrogels will be developed by novel advantageous methodology using in situ synthesis of hydroxyapatite in drug containing polymer solution and spray drying technology or freeze-thawing technique. The physicochemical and mechanical properties will be investigated, as well as biodegradation, drug release kinetics, cytocompatibility study and antibacterial activity will be performed. The obtained research results can be transferred in the development of high added value bone graft substitutes which are potentially transferable from laboratory to the biomedical product industry. The implementation of the proposed project will provide new knowledge and know-how of biomaterials research and development for bone tissue engineering applications.

ERDF project (1.1.1.1/16/A/144) "Influence of the magnetic field initiated stirring on biotechnological processes"

Project Leader. Leader: Dr. Juris Vanags, Latvian State Institute of Wood Chemistry, Bioengineering laboratory
Project Partner. Leader: Assoc. Prof., Dr.sc.ing. Dagnija Loca - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The aim of the project is to investigate the influence of the created field of the magnetic field initiated stirring on the growth and biosynthesis of microorganisms. Based on this information, determine the usability boundaries of magnetic drive for various sterile biotechnological processes. The conditions of sterility are crucial for the biotechnological processes. One of the most typical contamination points of the bioreactor is stirring drive mechanical sealing. For solving this problem, the magnetic drive stirrers are used. As a result, microorganisms circulate in direct contact with the magnetic rotor. Despite the perspective of this kind of application, no unequivocal information about the influence of the magnetic field-initiated mixing on microorganism growth and biosynthesis is available. Within the framework of the project, RTU is performing cultivation of mammalian cells and calculations of reactor scaling in connection with the use of magnetic rotors.

Multifunctional nano-calcium phosphate/hyaluronic acid hydrogels for osteoporotic bone treatment

Project leader: Assoc. Prof., Dr.sc.ing. Dagnija Loca - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The project aims to develop new, innovative three-dimensional calcium phosphate and hyaluronic acid cross-linked hydrogels with inorganic component up to 60 weight %, which would not cause inflammation in the surrounding tissues, promote angiogenesis processes and form new bone tissues. The scientific cooperation between Riga Biomaterials Innovations and Development Centre and Department of Pharmaceutical Chemistry of the Faculty of Pharmacy will provide in vitro and in vivo evaluation of the developed materials.

H2020 WIDESPREAD-04-2017- Teaming Phase 1 Project No. 763721 “Baltic Biomaterials Centre of Excellence”.

Project leader: Asoc.prof. Dr.sc.ing. Janis Loss, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Establishment of the Baltic Biomaterials Centre of Excellence (BBCE) under Horizon 2020 Teaming framework will provide an opportunity to combine expertise and infrastructure, to create critical mass and excel in the respective field and create spill-over effects between different fields. Hence BBCE project´s main objective is to establish a joint Baltic Biomaterials Centre of Excellence for advanced biomaterial development based on the long-term strategic cooperation between AO Research Institute Davos, Switzerland (ARI) and Friedrich-Alexander University of Erlangen- Nuremberg, Germany (FAU) on the one hand and three institutions from Latvia - The Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of Riga Technical University (RTU RBIDC), Latvian Institute of Organic Synthesis (LIOS) and Riga Stradins University, (RSU) on the other hand. The funding has been received for business plan development.

Post-doctoral research project “Drug and growth factor dual delivery from different biomaterial carriers for bone tissue engineering (2ForBone)”. 2018-2021

European Regional Development Fund within the Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”. No 1.1.1.2/VIAA/1/16/048
Project leader: Dr.sc.ing. Arita Dubnika RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The goal of the 2ForBone project is to develop an antibiotic drug and growth factor dual delivery systems on the basis of different biomaterial scaffolds (bioceramics, hydrogels and bone cements) and compare these systems, to develop better drug and growth factor biomaterial carriers than these, currently available for the bone tissue engineering in clinics. The study is designed in three stages, starting from material development till their characterization in vitro. Accordingly, direct comparisons among a material preparation and different characterization data (i.e. chemical, mechanical, release kinetics, cytotoxicity, etc) will be ensured. Project is implemented at RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre together with partner institutions: Biomaterials and Advanced Drug Delivery laboratory (Stanford University, USA BioADD), Laboratory of Pharmaceutical Pharmacology (Latvian institute of Organic synthesis, Latvia, LPP) and State Research Institute Centre for Innovative Medicine (Lithuania, IMC).

Development of innovative frost-durable concrete by using rubber microgranules

Project Leader. Leader: Dr.sc.ing. Genādijs Šahmenko, Institute of Materials and Structures
Project Partner. Leader: Dr.sc.ing. Kristaps Rubenis, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The aim of this project is to develop ready-to-use, economically viable concrete compositions with enhanced frost durability, by using rubber microgranules obtained from scrap tires to enhance frost durability of the concrete.  

Energy production from the food waste

Project Leader. Leader: Dr.sc.ing. Kristīne Ruģele, RTU Water Research Laboratory
Project Partner. Leader: Dr.sc.ing. Olita Medne, Institute of General Chemical Engineering

The project aims to develop a technology for the treatment of food waste with a high concentration of fats for biogas production. The scientific cooperation will be fostered between Institute of General Chemical Engineering and Water Research laboratory.

ERA-NET EU-LAC Health projekts “Efficient and affordable water treatment technologies to minimise waterborne diseases.

Project Leader. Leader: Linda Mežule, Water Research laboratory
Project Partner. Leader: Asoc.prof. Dr.sc.ing. Janis Loss, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The project aims to produce and demonstrate on a field- scale several point -of-use water treatment technologies that will be specially targeted to rural communities, affordable and easy to use. Within the project specially coated membranes with increased efficiency, titanium oxides electrodes and novel hybrid UV microfiltration system will be designed and evaluated for their efficiency to neutralize bacterial, viral and protozoan pollution. 

 

Finished projects:

EU and international programs
National Research Program Projects
Internships abroad
Contract work
RTU research projects